This analysis published in Gynecologic Oncology represents a prospective correlation between drug sensitivity to the combination of cisplatin and gemcitabine in patients with a mixture of platinum-sensitive and platinum-resistant disease. Results reveal a statistically significant correlation between drug sensitivity and time to progression. In addition, this publication revealed a statistically significant correlation between drug sensitivity and clinical response, as well as drug sensitivity and overall survival.
This drug combination, developed by Rational Therapeutics, received FDA approval in July 2006 predicated upon this landmark study and the subsequent GOG clinical trial written by Dr. Nagourney (Gyn Oncol, 2006).Further reading
This analysis in small cell lung cancer, published by investigators at the National Cancer Institute, utilizing laboratory techniques developed and applied at Rational Therapeutics, correlates survival with the use of the “in vitro best regimen” (IVBR).
With a 39 percent durable complete remission rate for patients receiving assay “sensitive” therapy, this remains one of the best outcomes in this lethal disease ever reported.Further reading